High carbohydrate consumption has been linked to NAFLD progression by upregulating the expression of key gene transcription factors that are involved in hepatic de novo lipogenesis (DNL), such as sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element binding protein (ChREBP) [11]. Here, MLXIPL is linked to metabolic dysfunction-associated steatotic liver disease.