GnRH peptidic analogues such as goserelin (Zoladex®), buserelin, leuprolide (leuprolein, Eligard®) and triptorelin (Triptodur®) have proven to be as effective as surgical oophorectomy in premenopausal advanced breast cancer [185,186,187,188]. This evidence concerns the gene GNRH1 and breast cancer.