In line with clinical observations revealing that the loss of expression of the protein Wnt-5a in primary breast tumors is associated with a faster tumor spread, the Wnt-5a-mimicking hexapeptide Foxy-5 (sequence: N–Formyl–Met–Asp–Gly–Cys–Glu–Leu–COOH) causes a significant reduction of breast tumor metastases in immunodeficient and immunocompetent mice [272]. This evidence concerns the gene WNT5A and breast neoplasm.