Accordingly, the blockade of EP4 by diverse small molecules including AH23848, ONO-AE3-208, GW627368X and RQ-15986 (Figure 3b), as well as the triterpenoid saponine Frondoside A, inhibits the proliferation and migration of breast tumor cells, prevents phenotype changes of breast cancer stem cells and reduces breast tumor-initiating capacity, growth and metastasis [89,90,91,92,93,94,95,96]. This evidence concerns the gene PTGER4 and breast neoplasm.