Preclinical data obtained with dual ETAR and ETBR antagonists in diverse tumors suggest, therefore, that this class of drugs could be a promising therapeutic option for cancer treatments given that they can target not only tumor cells, which typically express ETAR, but also components of the cancer-associated microenvironment such as vascular, lymphatic and inflammatory cells and fibroblasts, which all express ETBR [238]. This evidence concerns the gene EDNRB and cancer.