Principally found in extracellular fluids, lysophosphatidic acid (LPA) and its endogenous derivatives exert pleiotropic effects including cell proliferation, migration, invasion, differentiation and adhesion, through at least six class A GPCRs, namely LPA1–6, which also play an important role in mediating malignant behaviors in breast cancer [64,65]. This evidence concerns the gene LPAR1 and breast carcinoma.