GLP1R and Insulin resistance: In the same population, we intended to investigate and dissect out the relative contribution of inflammation, adipose tissue distribution, insulin resistance, and beta cell deterioration to persistent platelet activation, and evaluate, at equal degree of weight loss, if a treatment by a GLP-1 receptor agonist (GLP-1 RA) exert a greater impact than lifestyle changes on TX-dependent platelet activation and lipid peroxidation.