The main targets for this pathway are the ectoenzymes CD73, CD39, and CD38 which promote ADO formation, and also the downstream A2AR. The potential of targeting CD73 was shown by the observation that reducing the expression of CD73 in the ID8-ova ovarian tumor cell line increased their susceptibility to T cell mediated killing in vitro and in vivo. This evidence concerns the gene NT5E and ovarian neoplasm.