Koszalka et al. performed a broad study on the in vivo effect of A1R, A2AR, and A3R signaling in B16 melanoma in mice and found that the receptors contribute to the TME by modulating angiogenesis, neovascularization, and infiltration of immunosuppressive tumor associated macrophages (TAMs) [76]. The gene discussed is ADORA2A; the disease is neoplasm.