Several inflammatory cytokines, including TNFα; IL-6; IL-8; IL-18; and acute phase proteins such as C-reactive protein (CRP), serum amyloid A, and fibrinogen, as well as white blood cells (WBC), are detected at increased concentrations in the circulation of patients affected by COPD [25,26]. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.