The results in these two groups are probably related to the fact that the women in GDM group, due to pre-pregnant overweight and obesity and with normal carbohydrate results in the first trimester, remained under strict control, so that from 24–28 weeks of pregnancy after being diagnosed with GDM they were successfully treated with not only a proper diet but also with insulin. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.