The exposures to both DDVP and CPF in the present study resulted in differential effects on indirect metabolic markers (body weight, brain weight and brain-body weight ratio), AChE activities, ROS levels, NO levels, histoarchitecture an distributions of proliferative nuclei proteins in the hippocampus and the amygdala, and the anxiety-related behaviors, fear learning, and spatial working memory in the exposed rats. The gene discussed is ACHE; the disease is Anxiety.