A number of circulating pro-inflammatory cytokines have been implicated in pancreatic cancer cachexia including interleukin 6 (IL-6), interleukin 8 (IL-8), transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNFα), and monocyte chemoattractant protein-1 (MCP-1) [14,15,16,17]. This evidence concerns the gene TNF and familial pancreatic carcinoma.