Furthermore, intercellular adhesion molecule 5 (ICAM-5) has recently been identified to be indispensable for the entry of both sialic acid-dependent and independent EV-D68 and soluble ICAM-5 fragment inhibits EV-D68 infection in primary human bronchial epithelial cells, primary rat neurons and mouse brain tissue [8]. Here, ICAM5 is linked to infection.