SREBF1 and fatty liver disease: Accordingly, we investigated if the beneficial effects of pistachio consumption on hepatic steatosis could be due to changes in the expression of the transcription factors PPAR-γ and SREBP-1c with their target genes FAS and SCD1, which are the principal regulators of fatty acid synthesis, and FAT-P, which is involved in fatty acid uptake from the extracellular milieu [56].