NFE2L2 and malignant colon neoplasm: Some studies have pointed out the potential anti-inflammatory role of RWE in colon cancer cells through a pathway involving both an activation of the nuclear factor-erythroid 2-related factor-2 (Nrf2) pathway and an inhibition of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway [27] or through a disruption of colonic NADPH-oxidase NOX1 activation [28].