Especially, Vstat120, a soluble 120 kDa fragment containing five TSRs, can be generated by cleavage at the GPS motif of BAI1 and can function as an antiangiogenic and antitumorigenic factor, suppressing tumor growth and vascular density in glioma-xenografted mice (Figure 2D) [65]. This evidence concerns the gene ADGRB1 and neoplasm.