In vivo tumor growth in renal carcinoma is reduced in mice inoculated with Renca/BAI1 (mouse renal cell carcinoma cells (Renca) transfected with BAI1) compared to the Renca wild type, suggesting that exogenous BAI1 can suppress tumor growth via the inhibition of angiogenesis [67]. The gene discussed is ADGRB1; the disease is hereditary clear cell renal cell carcinoma.