Although the relevance of BAI2 and BAI3 to cancer has been less studied than that of BAI1, BAI2 has been found to be mutated in breast, lung, and ovarian cancers along with BAI1, and a mutation in BAI3 has been found in lung cancers through the systemic characterization of somatic mutations in the cancer genome [68]. This evidence concerns the gene ADGRB2 and cancer.