SPDEF and endometrial cancer: Furthermore, the expression of estrogen-responsive genes KIAA1324, MLPH, MSX2, SPDEF, TFF3, and PIGR were all significantly up-regulated in CTCF-altered endometrial cancers (p = 0.0004, 0.0007, 0.0032, 0.0009, 0.0122, and 0.0028 respectively, Figure 6F, Supplementary Figure S3K–P).