Closer examination of genes that were dysregulated in CTCF-altered cancers showed expression of the CTCF paralog CTCFL was decreased (p = 0.0167; Supplementary Figure S3D), the exemplar CTCF-regulated gene H19 was decreased (p = 0.0087; Supplementary Figure S3E), whilst no change was observed in ZFHX3 expression which is located adjacent to CTCF on chromosome 16q22 (Supplementary Figure S3F). This evidence concerns the gene H19 and cancer.