Importantly, expression levels of the tumour suppressor genes CDKN2A and PIK3CA, which are deleted or mutated in endometrial cancer [28,39], were decreased in CTCF-altered samples (p = 0.0006 and p = 0.0007, respectively; Figure 6G, Supplementary Figure S3G,H). The gene discussed is PIK3CA; the disease is endometrial cancer.