Of the 11 genes, six were selected which represented each of the five functional clusters: SNAP23, ACLY, G6PD, IL6, IRS2, and SREBF1. Comparative expression analysis of all these genes revealed significantly higher levels of G6PD (FC = 1.52), IL6 (FC = 2.28), and SNAP23 (FC = 6.55) transcripts and a lower level of the ACLY transcript (FC = 0.63) in the GDM/SIRT1(↑) group compared to the NGT group, whereas no significant differences were found between the groups with regard to IRS2 (FC = 2.62) and SREBF1 (FC = 0.34) expression. The gene discussed is ACLY; the disease is gestational diabetes.