SIRT1 and Hyperglycemia: For example, GDM and in vitro hyperglycemia were found to decrease SIRT1 production in fetal endothelial colony-forming cells (ECFCs) and human umbilical vein endothelial cells (HUVECs) [23], while resveratrol was shown to impair GDM symptoms, such as hyperglycemia and insulin resistance, in the db/+ genetic GDM mouse model [24].