SIRT1 and gestational diabetes: More speculatively, it seems logical that the leukocyte ACLY down-regulation observed in the GDM/SIRT1(↑) group in the present study might lead to impaired de novo lipogenesis; in addition, the GDM/SIRT1(↑) pregnancies also demonstrated lower leukocyte SREBF1 expression than the NGT controls, although this change was not significant.