To identify a transcriptional signature associated with leukocyte SIRT1 overexpression, the Human Diabetes RT2 ProfilerTM PCR Array was used to compare the expression profile of diabetes-related genes in leukocytes from hyperglycemic GDM/SIRT1(↑) patients (n = 9) with that of the NGT subjects (n = 7). This evidence concerns the gene SIRT1 and diabetes mellitus.