SIRT1 and gestational diabetes: To further clarify the metabolic and transcriptional rearrangements associated with leukocyte SIRT1 overexpression during GDM, a stratified expression analysis of leukocyte SIRT1 status was performed in the GDM patients, which allowed a GDM/SIRT1(↑) (n = 30) group to be discriminated from a GDM/SIRT1(↔) (n = 92) group.