In an in vivo model of PD (i.e., systemic administration or striatal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)) translocation of p67phox was induced and p47phox phosphorylation and p47phox–gp91phox complexes were also significantly increased in mice substantia nigra (SN) [137]. The gene discussed is NCF1; the disease is Parkinson disease.