DUOX1 and immune system toxicity: In this study, FNT induced oxidative stress by enhancing expression of NOX-2 and DUOX-1 in splenic cells stimulated with Con A (Figure 7A,B), resulted in the immunotoxicity, such as inhibition of proliferation and production of T cell–related cytokines (Figure 1, Figure 2, Figure 3 and Figure 4).