IL1B and plasma cell myeloma: Indeed, bL showed inhibitory activity on TNFα secretion from macrophages induced by lipopolysaccharide (LPS) [58], on secretion of IL-6, IL-1β, and MMPs (MMP3, MMP8, and MMP9) from activated microglia [59], on secretion of VEGF in human multiple myeloma cells [60], and related signaling pathways such as nuclear factor kappa B (NF-κB) activation.