GLI2 and pachyonychia congenita: Moreover, this study also showed that GLI2 appeared to play a critical role in both anti-apoptosis and growth promoting of the PC cells through modulation of apoptosis-related genes, such as Bcl2, Bcl-xL, and clusterin, and through regulation of levels of cell cycle regulators, such as cyclin D1, p27, and PKC, respectively [25].