Plasma ET-1 levels were positively associated with age (Fig 1A), male gender, smoking history, serum T3 and T4 (Fig 1B–1C), hyperthyroidism, euthyroid AF, AF associated with hyperthyroidism, HT, CAD, and use of aspirin, beta blockers, and carbimazole. The gene discussed is EDN1; the disease is coronary artery disorder.