For flaviviruses, a few intrinsic anti-viral factors have been described: YTHDF1-3 proteins that bind methylated RNA and regulate stability, were reported to interact with ZIKV RNA and inhibit infection (Lichinchi et al., 2016); YB-1 and QKI bind to the DENV 3′ UTR and repress DENV RNA translation (Liao et al., 2018; Paranjape and Harris, 2007); similarly, FBP1 blocks translation of JEV through interacting with untranslated regions of JEV RNA (Chien et al., 2011). The gene discussed is YTHDF1; the disease is infection.