Furthermore, mRNA levels of the lactate transporter, monocarboxylate transporter 5, Slc16a4, were also increased in eWAT of HF-fed EC-FoxO1 KD mice (Figure 6K), consistent with an increased glycolytic flux of glucose to lactate in the adipose tissue of these mice. The gene discussed is SLC16A4; the disease is hydrops fetalis.