HF-fed EC-FoxO1,3 KD mice (generated using the tamoxifen-inducible, endothelial-specific Cre driver: Pdgfb-CreERT2) presented lower levels of fasting glucose (Figure 9A–C) and reduced adiposity, as evidenced by lighter subcutaneous and rWAT depots, compared to their littermate controls (Supplementary file 1). Here, FOXO1 is linked to hydrops fetalis.