Of note, the increase of vessel diameter in HF-fed EC-FoxO1 KD mice was greater than observed in NC-fed EC-FoxO1 KD mice (1.8 vs. 1.3-fold increase), suggesting that the enlargement of capillaries promoted by EC-FoxO1 depletion is exacerbated by HF feeding. Here, FOXO1 is linked to hydrops fetalis.