Moreover, histological analysis revealed that increased vascular growth in adipose tissue of HF-fed EC-FoxO1 KD mice was associated with smaller-sized and generally spherical adipocytes, whereas adipocytes from HF-fed control mice were large with irregular polygonal shapes (Figure 5D–E), which was previously related to cellular stress (Giordano et al., 2013). Here, FOXO1 is linked to hydrops fetalis.