Interestingly, fasting glycemia was significantly lower (Figure 6I) whereas serum lactate levels were elevated in HF-fed EC-FoxO1 KD mice compared to their littermates (10.9 ± 0.39 vs. 9.4 ± 0.55 mmol/L, respectively, p = 0.04, n = 7/group). The gene discussed is FOXO1; the disease is hydrops fetalis.