HF-fed EC-FoxO1,3 KD mice (generated using the tamoxifen-inducible, endothelial-specific Cre driver: Pdgfb-CreERT2) presented lower levels of fasting glucose (Figure 9A–C) and reduced adiposity, as evidenced by lighter subcutaneous and rWAT depots, compared to their littermate controls (Supplementary file 1). The gene discussed is PDGFB; the disease is hydrops fetalis.