MURC was demonstrated to play a vital role in cardiac hypertrophy.11 Schlegel et  al reported that elevated expression of G protein‐coupled receptor kinase 2 induced cardiac hypertrophy.23 In this study, we demonstrated that Ang II, ERK and MURC played a crucial role in hypertrophy under stretch conditions in cardiomyocytes. Here, AGT is linked to cardiac hypertrophy.