Overexpression of MURC swelled the caveolae but was not crucial to caveolae formation.7 MURC was found to be expressed in vascular smooth muscle cells, skeletal muscle cells and cardiomyocytes.8 A study suggested that pressure overload could induce MURC messenger RNA (mRNA) expression in cardiomyocytes.9 Overexpression of MURC in a transgenic mouse model led to atrial fibrillation and chronic heart failure.10 Ogata et  al reported that MURC was involved in the cardiac concentric hypertrophy under pressure overload.11 The gene discussed is CAVIN4; the disease is atrial fibrillation.