β‐Catenin protein is upregulated in disc tissue samples from patients with IDD; β‐catenin conditional activation in mice showed severe defects in intervertebral disks and the expression of MMP‐13 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS‐5) were increased (Wang et al., 2012). Here, MMP13 is linked to intervertebral disk degenerative disorder.