Of the 21 DTC/PDTC patients, 16 had neck US abnormalities and/or biochemical disease (elevated serum thyroglobulin [Tg] levels or rising anti-Tg antibodies [TgAb] levels), three had metastatic disease under surveillance and two were at high-risk [8] before first radioiodine administration. The gene discussed is TG; the disease is metastatic neoplasm.