Despite the observation by Tang and colleagues that activation of the KEAP1-NRF2 pathway protects hepatocellular carcinoma cells against ferroptosis46, in our hands knockdown of NRF2 in HeLa cells did not show obvious alterations in their sensitivity towards BFA relative to control knockdown cells (Supplementary Fig. 3g). The gene discussed is KEAP1; the disease is hepatocellular carcinoma.