In addition Galunisertib, through the suppression of SMAD2 phosphorylation, restored the expression of DNAM-1, NKp30, and NKG2D cytotoxicity receptors and the TRAIL death ligand in NK cells, stimulated the release of perforin and granzyme A by the latter cells and enhanced NK cell-mediated cytotoxicity and ADCC against NB cells. Here, TNFSF10 is linked to neuroblastoma.