In the same melanoma models, authors demonstrated that combining immune checkpoint blockade using anti-CTL-A4 and an immunocytokine (IC) consisting of the anti-GD2 Ab 14.18 and IL-2 (14.18-IL-2 IC) induced tumor regression in the B78 melanoma model, resulting in a survival rate of about 40% of tumor-bearing mice. The gene discussed is IL2; the disease is melanoma.