CD274 and neoplasm: This, together with the positivity for PDL1, which is known to have immunosuppressive functions and is instrumental in the induction and functional activation of tumour-induced Tregs, suggests that ELSs may play a dual role in E-MpMs: in addition to recruiting T cells from the circulation, they may also sustain the immunosuppressive traits of E-MpMs [25, 26].