EZH2 and glioblastoma: However, the study of the HIF-EZH2 interplay is complicated by the observation that, in glioblastoma, EZH2 activates HIF-1α expression by inhibiting the eleven-nineteen lysine-rich leukemia associated factor 2 (EAF2) that, in the prostate, regulates transcriptional elongation of RNA Poll II (82).