In fact, in this way, it has been possible to demonstrate that the deletion of EZH2 accelerates de novo MB development and the progression of established MBs and that EZH2 inactivation in G3 MB implicates Gfi1 (a proto-oncogene frequently activated in human G3 MBs whose disruption antagonizes the tumor promoting effects of Ezh2 loss) as an oncogenic target gene. Here, EZH2 is linked to neoplasm.