EZH2 and breast carcinoma: Furthermore, a specific genomic aberration mediated by EZH2-impaired DNA damage response has been linked to the expansion of BTICs and, finally, it has been possible to show a previously unidentified therapeutic effect of the inhibitors of RAF1-ERK signaling (e.g., AZD6244, a specific MEK/ERK inhibitor, already tested in multiple clinical trials) to prevent breast cancer progression by eliminating BTICs with important clinical implications (79).