These data suggest that high levels of ΔNp63α are expressed in pediatric neuroblastoma and osteosarcoma, ΔNp63α has oncogenic effects in neuroblastoma and osteosarcoma, ΔNp63α regulates VEGF activity and promotes migration, induces STAT3 phosphorylation, and increases the transcription of interleukin (IL-6 and IL-8), and that ΔNp63 expression is enhanced in osteosarcoma lung metastases (70). This evidence concerns the gene STAT3 and osteosarcoma.