PRDM9 and cancer: Enhancer of zeste homolog 2 is the catalytic subunit of the PRC2, a highly conserved histone methyltransferase, involved in the methylation of lysine 27 of histone 3.The overexpression of EZH2 has been correlated with many cancers, such as prostate, breast, bladder, whereas other kinds of cancer, such as B-cell lymphomas or other forms of breast cancer, can be promoted by specific mutations (10).