HHV-6A and HHV-6B provide other examples of mislocalization coupled to cell cycle arrest, as their infection reduces E2F1-Rb complex formation and leads to accumulation of E2F1 both in the cytoplasmic and nuclear fractions, as opposed to its strict nuclear localization in normal cells (Mlechkovich and Frenkel, 2007). The gene discussed is E2F1; the disease is infection.