Formation of a complex between the core protein of hepatitis C virus (HCV), which plays an important role in the development of hepatocellular carcinomas, and p21WAF1/CIP1 was mapped to the C-terminus of this CKI, a region in the close vicinity of the PCNA binding site of p21WAF1/CIP1 (Wang et al., 2000). Here, CDKN1A is linked to hepatocellular carcinoma.