For example, varicella-zoster virus (VZV), an alpha-herpes virus that causes varicella and zoster, targets the MED25 subunit of Mediator through its major transactivator protein, immediate early gene 62 (IE62) (Yang et al., 2008), whereas herpes simplex virus utilizes VP16, which controls the transcription of immediate early genes, to activate transcription through a specific MED25-associated mediator deficient in CDK8 (Uhlmann et al., 2007). The gene discussed is MED25; the disease is chickenpox.