The accessory protein viral infectivity factor (Vif) of HIV-1 also inhibits cell cycle progression at the G2 phase by interfering with the nuclear translocation of CDK1 and cyclin B1, a finding corroborated by infection experiments with Vif-deficient HIV-1 virus that point to a role of this viral protein in mediating CDK1 cytoplasmic-retention (Sakai et al., 2011). Here, CDK1 is linked to infection.