Knockdown of Beclin 1 via RNA interference decreased K5-induced autophagy but accelerated K5-induced apoptotic cell death, which suggests that interfering with the autophagic survival response can potentiate the antiangiogenic effects of K5 in endothelial cells, leading to a potential antitumor effect.95 Similarly, sulforaphane (SUL), an isothiocyanate, has pro-apoptotic and pro-autophagy effects on tumor vascular endothelial cells. Here, KRT5 is linked to neoplasm.