However, currently, RTL‐related DM studies using alloxan‐induced models are predominant (Ananthakrishnan & Doss, 2010, 2013; Shahwara et al., 2011), and a few surveys have explored the effect of RTL on the HFD‐fed STZ‐induced T2DM paradigm and the IR mechanism via inflammation, causing TNF‐α activation in skeletal muscle cells. The gene discussed is TNF; the disease is type 2 diabetes mellitus.