After 4 weeks of treatment, the serum insulin levels of the DM + Pio, DM + W100, DM + W400, and DM + E400 groups were 0.10 ± 0.03, 0.16 ± 0.07, 0.24 ± 0.05, and 0.29 ± 0.15 μg/L, respectively, which were significantly lower than that of the DM group (p < 0.05). The gene discussed is INS; the disease is diabetes mellitus.