In another study comparing cancer cell lines – low-grade type-I Ishikawa cells, high-grade type-I SK-UT2 cells, and type-II AN3CA cells, with benign endometrial epithelial cells, all endometrial cancer cell lines expressed higher levels of Ob-R in contrast to benign cells (Carino et al., 2008). The gene discussed is LEPR; the disease is endometrial cancer.