NOS2 and myocardial infarction: Study demonstrated that ischemic preconditioning upregulated iNOS expression in cardiomyocytes [45], and in conscious rabbits, the beneficial effects of late preconditioning against myocardial infarction were abrogated by the NOS inhibitor (Nw-nitro-L-arginine) and iNOS inhibitors (aminoguanidine and S-methylisothiourea) [10, 46], suggesting that iNOS is an essential mediator of such cardioprotective responses.