Some neurodegenerative diseases, such as AD, are associated with oxidative stress and neuroinflammation, and proteins that are closely related to this neurological disorder (i.e., AMPK, SIRT1, and PGC-1α) can be modulated by resveratrol [152]; however, there are few clinical studies on resveratrol in AD patients. Here, SIRT1 is linked to Alzheimer disease.