ccRCC is frequently associated with the von Hippel-Lindau (VHL) tumor suppressor mutational loss of function and subsequent accumulation of hypoxia-inducible factor (HIF) proteins, leading to the aberrant activation of HIF target genes that regulate angiogenic factors (vascular endothelial growth factor A, epidermal growth factor receptor type 1, platelet-derived growth factor B chain, and transforming growth factor), glycolysis, and apoptosis [122]. Here, VEGFA is linked to neoplasm.