Interestingly, this new preclinical tool has provided new insights into translational medicine, corroborating the involvement of mTOR pathway (mTORC1–CDK1/cyclin axis) in ADPKD pathophysiology and the efficacy of rapamycin treatment protocols in the improvement of mice survival, cystic phenotype, and renal function [106]. The gene discussed is MTOR; the disease is autosomal dominant polycystic kidney disease.