INS and Hyperglycemia: Other relevant metabolic side effects of rapamycin should be also noticed at this point, including hyperglycemia, insulin resistance, and dyslipidemia, which seem to be related to glucose and lipids metabolism in the pancreas and in the peripheral insulin resistant tissues (liver, adipocyte tissue, and muscle), as previously reported in animal and human studies, some of them from our own group [37, 144–150].