CD4 and allergic asthma: In contrast to the composition of IL-10-producing LAG3+CD49b+ T cells induced by Nb infection, in which the Foxp3− CD4+ subset is the majority (72% in Figure 2D), in HDM-induced allergic asthma model, the largest subset of the IL-10-producing LAG3+CD49b+ T cells in the lungs are Foxp3+ CD4+ T cells (60%), followed by Foxp3− CD4+ T cells (32%), while CD8+ T cells are only around 1.4% (Figure 3B).