Our previous studies found that NLRP3/IL-1β signaling in peritoneal macrophages promoted OVA-induced allergic asthma through recruiting inflammatory monocytes and neutrophils into peritoneal cavity after OVA/alum sensitization, and inflammatory monocytes played a dominant role to determine the outcome of OVA-induced allergic asthma (28), which was further confirmed in this study. The gene discussed is IL1B; the disease is allergic asthma.