Yu et al. showed that SIRT7 specifically interacts with and deacetylates FK506-binding protein 51 (FKBP51) at lysine residues 28 and 155 (K28 and K155), which enhances FKBP51–Akt–PHLPP complex formation, resulting in AKT inactivation and enhanced chemo-sensitivity in breast cancer cells (16). Here, SIRT7 is linked to breast carcinoma.