SIRT7-knockout mice have a shorter lifespan than control mice, and succumb to premature aging phenotypes around 1 year, with symptoms, such as kyphosis, decreased gonadal fat pad content, reduced IGF-1 plasma levels, hepatic steatosis, degenerative heart hypertrophy, reduced hearing and reduced hematopoietic stem cell–regenerative potential (13, 46, 65). This evidence concerns the gene SIRT7 and fatty liver disease.