ESR2 and autism: It has been reported that ERβ dysregulation in the brain has been found in ASD subjects (20), and, very interestingly, we have recently reported that prenatal exposure of either levonorgestrel (LNG) (19) or any of the other 8 kinds of synthetic progestins (21) induces autism-like behavior in offspring through ERβ suppression in rats (19, 21).