NR3C1 overall methylation level (blood and saliva) was associated with higher levels of internalizing disorders. Hypermethylation (blood and saliva) of CpG10 was associated with higher internalizing symptoms. CpG3 and CpG4 hypermethylation (saliva) predicted externalizing severity. Elevated morning cortisol plasma levels were associated with increased methylation of CpG9 (blood). The gene discussed is NR3C1; the disease is internalizing disorder.