NR3C1 and Borderline personality disorder: NR3C1 further was the only gene that was as well affected in one of the GWA (29), however this was mediated by methylation differences of miR124-3 which targets, among other genes, on NR3C1. In contrast, GWA studies, as performed by Teschler and Prados, found large number of genes that were differentially methylated in BPD, indicating a system-wide involvement in PD including genes associated with immune-response, cell-signaling or transcription control (27–29).