Significant association of CPA with methylation aberrances in a plenty of genes, many involved in immune and inflammatory responses such as FOS, GATA1, GATA3, HGF, TNF, IFNG, IL1A, IL1B, IL17R, IL10, IL13, and IL18. Methylation differences were aggression-associated in 31 promoter sites in both woman and men, i.a. TPH2, CRHBP, NR3C1 (less methylated in the CPA group). One CpG site was significantly associated with aggression in both women and men, but was differentially deviant methylated (ZNF366 promoter region). Here, TPH2 is linked to congenital primary aphakia.