A total of 917 probes corresponding to 430 distinct gene promoters were differentially methylated, of which many are involved in immune and inflammatory responses such as FOS, GATA1, GATA3, hepatocyte growth factor (HGF), TNF, IFNG, IL1A, IL1B, IL10, IL13, IL17R, and IL18. Thereof, some had previously been shown to be associated with aggressive behavior, including Tryptophan hydroxylase 2 (TPH2), NR3C1, and Corticotrophin-releasing hormone-binding protein (CRHBP), all of them were significantly less methylated in the CPA subjects. The gene discussed is CRHBP; the disease is congenital primary aphakia.