We showed earlier the efficiency of MNT DTox-HMP-NLS-EGF for its EGFR-mediated cell recognition and endocytosis and endosome escape, along with accumulation of the MNT in the cell nuclei of target cancer cells with EGFR overexpression in vitro (Gilyazova et al., 2006; Slastnikova et al., 2012a; Koumarianou et al., 2014) and in vivo (Slastnikova et al., 2012b). Here, EGFR is linked to cancer.