IDH2 and central nervous system cancer: Additionally, dominant negative p53 can force quiescent stem cells to proliferate and but do not lead to cell differentiation (Ehtesham and Khan, 2015), and in combination with IDH R132H substitution leads to cancer transformation reminiscent of low-grade gliomas (IDH1-mutant TP53 lost astrocytomas; Modrek et al., 2017).