CD44, CD133 and LGR5 are characteristic cell surface markers of glioma CSCs (Lathia et al., 2015), which are either receptors for cWnt pathway (LGR5), or function as positive regulators of Wnt receptors (CD44; Schmitt et al., 2015), or E-cadherin (CD133; Brossa et al., 2018). This evidence concerns the gene LGR5 and central nervous system cancer.