Additionally, the glioma CSC secretome was found to change during distinct differentiation stages and it was demonstrated that quiescent glioma CSCs do not secrete any cytokines, but maturation stimulation causes them to produce different cytokines at different times, beginning with the production of EGF on the 2nd day of differentiation, MCP1 on the 3rd, VEGF on the 4th, IL8 on the 9th and PDGF on the 18th day of differentiation (Kwak et al., 2013). Here, EGF is linked to central nervous system cancer.