TP53 and astrocytoma (excluding glioblastoma): IDH-mutant gliomas diagnosed as primary GBMs are likely progressed astrocytomas that evaded earlier diagnosis (Ohgaki and Kleihues, 2013), as they frequently contain astrocytoma signature mutations—IDH1 (85%), TP53 (81%) and ATRX (71%; Liu et al., 2012).