Some studies link working memory impairment observed both in juvenile and adult rats subjected to prenatal hypobaric hypoxia with increased levels of phosphatidylinositol 4,5-diphosphates and phosphatidylinositol 4-phosphates in the hippocampus and upregulated expression of the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) (Tyul'kova et al., 2015). Here, ITPR1 is linked to memory impairment.