UBE3A and neoplasm: It involves the assembly of a ternary complex of E6 with p53 and the cellular ubiquitin ligase E6AP in a precise temporal sequence of molecular events: once E6 is bound to E6AP, the heterodimer E6/E6AP recruits p53 and causes its enhanced ubiquitination and accelerated proteasomal degradation, leading to the loss of tumour suppressor functions and therefore contributing to neoplastic process2,3.