The role of eosinophils in early MM is further supported by the finding that progression to MM was delayed in early-MM Vk*MYC mice only if treated with the combination of antibodies specific for IL-17, IL-17RA, and IL-5, and therapeutic efficacy correlated with a reduced BM accrual of both Th17 cells and eosinophils. Here, MYC is linked to Miyoshi myopathy.