As the role of IL-5 as growth factor for myeloma plasma cells is debated43,58, and IL-5 should not impact on BM stromal cells, one mechanism by which anti-IL17, anti-IL-17RA, and anti-IL5 antibodies acted in Vk*MYC mice is a reduced accrual and survival of eosinophils and consequently of Th17 cells. This evidence concerns the gene IL17A and plasma cell myeloma.