Whereas the frequency of both Kaede red+ (i.e., IL-17+ cells migrated from the gut) and Kaede green+ (i.e., non-photoconverted IL-17+ cells) cells within CD3+CD4+ cells (Supplementary Fig. 4) was similar in the spleen of both control and Vk12598-challenged mice (Fig. 1l), Kaede red+ cells substantially increased in the BM of tumor-bearing mice (Fig. 1m), thus demonstrating that the presence of MM induced migration of IL-17+ cells from the gut to the BM. The gene discussed is CD4; the disease is neoplasm.