Variable results were also observed after overexpression of β-syn using a lentiviral vector after inoculation into the hippocampus of transgenic mice overexpressing a mutated form of the human β-amyloid precursor protein (APP) involved in Alzheimer’s disease, as assessed by examining plaque load, memory deficits, and anxiety24. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.