Moreover, genes associated with either stem cell maintenance or stem cell differentiation (Fig. 3f, left and right panels, respectively) show large changes in AF versus 2i/L in MTCH2F/F cells (left columns in both panels) as opposed to relatively small or no changes in MTCH2−/− cells (right columns in both panels; note the many black lines that represent no difference). This evidence concerns the gene MTCH2 and atrial fibrillation.