TNF and acute myeloid leukemia: In addition, cytokine analysis of supernatants of AML-PBMCs treated with midostaurin showed a change in IFN-γ (N = 5, 25% decrease, P = 0.002), TNF-α (N = 3, 10% increase, P = 0.42), and IL-10 (N = 2, 50% decrease, P = 0.001) when compared to the control group (Fig. 4D).