It is also worth to note that lncRNA HAND2-AS1 may interact with multiple functional molecules in the regulation of migration, invasion and stemness of NSCLC cells due to the fact that exogenous TGF-β1 only partially not totally reversed the inhibitory effects of lncRNA HAND2-AS1 overexpression on migration, invasion and stemness of NSCLC cells. This evidence concerns the gene HAND2 and non-small cell lung carcinoma.