During an average follow-up period of 14.7 years, 12,067 BC cases (7210 ER+ tumors, 1598 ER- tumors, and 3259 tumors with unknown ER status), 16,929 primary cancers at other sites, and 6548 deaths from non-cancer causes were ascertained among the EPIC women, as reported in Table 1. The gene discussed is ESR1; the disease is breast cancer.